ABSTRACT
Background: Some prospective studies have observed associations between periodontal disease and breast cancer. Therefore, the aim of the present study was to investigate the composition of the subgingival biofilm of women diagnosed with breast cancer, who also presented with chronic periodontitis. Methods: All subjects underwent clinical and microbiological assessment. Subgingival biofilm samples were taken from at least three sites of 44 women who had breast cancer. The mean levels and proportions of 40 bacterial species were determined by checkerboard DNA-DNA hybridization. Spearman correlation was used to assess possible associations between the mean levels of bacterial species and clinical conditions. Results: The five species found at the highest levels were Prevotella nigrescens, Actinomyces gerencseriae, Neisseria mucosa, Porphyromonas gingivalis and Tannerella forsythia. The species detected in the lowest counts were Propionibacterium acnes, Streptococcus constellatus, Streptococcus intermedius, Eubacterium saburreum and Streptococcus anginosus. No significant association between levels and proportion of bacterial species and clinical parameters were found. Conclusion: In conclusion, the results of the present study found no direct association between the subgingival microbiota and breast cancer and an indirect pathway should be addressed in further studies.
Subject(s)
Humans , Female , Adult , Aged , Aged, 80 and over , Breast Neoplasms , Chronic Periodontitis , Periodontal Diseases , Cross-Sectional Studies , Risk Factors , Microbiological TechniquesABSTRACT
A doença periodontal é um processo inflamatório crônico dos tecidos periodontais, causada por bactérias gram-negativas anaeróbicas presentes no biofilme dentário. Esse foco infeccioso pode manifestar-se em sítios corporais distantes ou sistêmicos, quando essas bactérias alcançam a corrente sanguínea. Os objetivos desse estudo de revisão são: demonstrar a relação entre doença periodontal e prematuridade, o efeito do tratamento periodontal sobre o nascimento de prematuros, e se microrganismos periodontopatogênicos são capazes de induzir efeitos adversos na gravidez quando os mesmos são encontrados na placenta. Esse estudo constituiu-se de uma revisão da literatura com artigos científicos selecionados através de bancos de dados Scielo, Bireme, Medline e Lilacs, publicados nos anos de 1980 a 2013. Entre os estudos selecionados, todos relacionaram a doença periodontal como sendo um fator de risco importante a ser considerado na gravidez, pois a presença de patógenos orais associou-se à prematuridade, baixo peso fetal ao nascer e infecções perinatais. Portanto, segundo a literatura consultada, a infecção periodontal em mulheres grávidas não deve ser negligenciada pois, se essa doença favorece complicações gestacionais, a atenção à saúde periodontal das gestantes deve estar incluída nas ações de cuidados do pré-natal.
Periodontal disease is a chronic inflammatory process of periodontal tissues caused by gram- negative anaerobic bacteria present in the biofilm. This infection may occur in distant or systemic body sites, when these bacteria reach the bloodstream. The aims of this review study are to demonstrate the relationship between periodontal disease and preterm birth, the effect of the periodontal treatment on preterm birth, and whether periodontopathogenic microorganisms can induce adverse effects on pregnancy when they are found in the placenta. This study is a literature review with scientific papers selected through Scielo Bireme, Medline and Lilacs databases and published between 1980 and 2013. All selected studies considered the periodontal disease as an important risk factor for the pregnancy, since the presence of oral pathogens was associated with premature birth, low birth weight and perinatal infections. Therefore, according to the literature, periodontal infection in pregnant women should not be underestimated, because it favors pregnancy complications, and periodontal health care to pregnant women should be included in the prenatal care.